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Cholesterol metabolism significantly contributes to cancer progression

Therefore, we hypothesized that hindering S114 phosphorylation by RNAi depletion of a kinase would enhance the transcriptional activity of NHR-49

In this context, natural compounds such as polyphenols have emerged as promising candidates due to their multifaceted mechanisms of action, including antioxidant, antiinflammatory, and neuroprotective properties

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Selectivity and affinity are the main advantages of biological ligands

Author contributions YZ and CF planned the experimental protocol and finished the manuscript