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Gene ontology and pathway analysis revealed that 26% of CR responded DEGs are involved in malignancy and cancerassociated networks The 26% (121/467) of DEGs were characterized in IPA (Supplementary Table S5)

In hyperpigmentation, the dark areas are lightened by inhibiting the formation of melanin

DOI: 10.1111/j.1399-3054.1994.tb03042.x [2] Glutathione: Metabolism and function[J]

Hepatol Commun

Glutaminase-mediated glutamine deamination leads to glutamate formation which then participates in metabolic pathways that generate other nitrogen-rich molecules

Additionally, incubation of vitamin C and individual crystallins results in the glycation and cross-linking of isolated lens crystallins (57)