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This interaction suggests that disruption of the SKI complex, due to factors such as FOCAD (9p21.3) deletion or microsatellite instability-high (MSI-H) status, creates a dependency on PELO and HBS1L for tumor cell Survival

doi: 10.1038/s41366-021-00820-7 98 ClemmonsDR

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As we age or face chronic stress, poor nutrition, or environmental toxins, our natural glutathione levels can become depleted