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Results Targeting of the common marmoset LRRK2 gene using CRISPR/Cas9 To evaluate whether it was feasible to introduce the PD LRRK2 G2019S mutation in the marmoset genome, we first compared marmoset and human LRRK2 protein sequences

[DOI] [PMC free article] [PubMed] [Google Scholar] 1163.Siegert A, Rosenberg C, Schmitt WD, Denkert C, Hauptmann S

The methylation pathway involves the SAM-dependent enzyme histamine N -methyltransferase which is encoded by the HNMT gene

Whereas deletion of mLST8 or RICTOR, which specifically inactivate mTORC2, compromised the phosphorylation and stability of PKC (Guertin et al., 2006), mTORC2 has been indicated to be a positive regulator of PKC (Gan et al., 2012)

The SL, RL, FW and DW are important parameters for the classification of tolerance 47