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doi: 10.1067/mtc.2003.30 70 AlbaACTinckamKForoutanFNelsonLMGustafssonFSanderKet al

To call it vital would be an understatement

Diabetes mellitus is an example where both these mechanisms occur simultaneously

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Homocysteine levels can be high for a number of reasons:[ref][ref] Insufficient folate and B12 (exacerbated by variants in MTHFR, MTR see genotype report below) Not enough B6 (CBS pathway, B6 see genotype report) More methionine than the body can handle Renal insufficiency (kidney disease) or alcoholism Genetic mutations in the CBS gene can cause rare cases of hyperhomocysteinemia

Although Grx are mainly responsible for deglutathionylation reactions, recent evidence has indicated a role for Grx in protein glutathionylation, mediated by the stabilization of a GSH thiyl radical which is then subsequently transferred to an available protein thiol (Starke et al., 2003)