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In a study using intracerebroventicular administered streptozotocin-induced dementia in rats, both pre- and post- treatment of curcumin (200 mg/kg) restored memory functions and brain insulin receptors [299]

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It inhibits the thioredoxin-interacting protein (TXNIP), a key regulator of ROS production, which in turn downregulates the NLRP3 inflammasome, reducing inflammation and oxidative stress-induced tissue damage

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