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This principle extends to discussions about supplements

Disruption of endothelial integrity is typically incurred during graft harvesting due to mechanical trauma, and, although also described in free arterial grafts ( Endothelial injury leads to activation of a platelet-mediated thrombotic cascade (Figure 1) ( Antithrombotics in the prevention of graft thrombosis Aspirin Aspirin is a non-selective, irreversible cyclooxygenase inhibitor that prevents downstream prostaglandin and thromboxane A 2 synthesis, thus inhibiting platelet aggregation (Figure 2)

doi: 10.1038/nbt.2530 9 WarburgO

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