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Steven Heymsfield et al noted that many factors can influence individual changes in FFM relative to weight lossincluding dietary intake, physical activity, aging, the metabolic and hormonal stateand individual factors like adiposity, race, and sex. Tracking body composition changes during GLP-1 receptor agonist induced weight loss has become increasingly needed in the context of muscle tissue loss

Christian Hendershot, director of clinical research at the USC Institute for Addiction Science, who wasnt involved in the new research but has run trials of GLP-1s in addiction

Nausea, appetite loss, and constipation are most frequent during weeks 1 to 3, typically resolving by week 4 to 6 as your body adjusts

it is not an instant effect for a few reasons: The medication needs time to build up blood levels that work

By activating GLP-1 receptors, these medications reduce hunger signals, increase feelings of fullness, and help regulate blood sugar

Both are GLP-1 medications, but tirzepatide targets an additional hormone receptor (GIP), which studies show can produce greater average weight loss