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Similar content being viewed by others Key facts Brain cancer cells (including cancer stem cells (CSCs)) from glioblastoma (GBM) and medulloblastoma (MB), rely on high iron uptake and storage to support proliferation, survival, and stemness and thus exhibit an iron addiction

Overexpression of GAPDH is a characteristic associated with accelerated proliferation in many tumors, such as breast, lung, pancreatic, and esophageal tumors, suggesting GAPDH as an attractive target for the treatment of tumors (Li et al., 2020)

When metabolic pathways are inhibited, cells activate autophagy to break down cellular components and release amino acids, fatty acids, and other nutrients that can be reutilized

S8), and the correlation of the localization of PilQ (by immunolabelling) with the nozzles (by electron microscopy) to isolated cross walls or whole cell filaments (compare Fig

Sci Rep 6 , 18358 (2016)

However, scientists dont fully understand the underlying mechanisms that drive these effects