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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism
PMCID: PMC6359887
116,238,239 High-dose intravenous (IV) steroids may also be useful in patients who do not respond to conventional treatment
The healthcare provider will determine the appropriate starting dose
5-Amino-1MQ , short for 5-Amino-1-methylquinolinium , is a small molecule peptide analog that inhibits the enzyme nicotinamide N-methyltransferase (NNMT)
