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A large meta-analysis of 66 RCTs found curcumin/turmeric supplementation significantly reduced levels of inflammatory markers, including C-reactive protein, tumor necrosis factor, and interleukin-6, and improved antioxidant activity compared to placebo [86]

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These effects may be particularly relevant in patients with comorbid obesity and obstructive sleep apnea (OSA), conditions frequently co-occurring with SUDs such as alcoholism and opioid dependence [36,37]

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Metabolic health improvements: 98% of patients improved at least one metabolic marker, and 78% of those with prediabetes or diabetes normalized their hemoglobin A1c levels at 12 months

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