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Higher doses produce increased incidence and severity of gastrointestinal symptoms, which explains why clinical protocols use gradual dose escalation starting at 0.25 mg weekly and incrementally increasing every 4 weeks

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doi:10.4172/2325-9604.1000112

Pox virus protein synthesis proceeds within cytoplasmic enclaves inside infected cells, and does not have the benefits of orderly testing of the thermodynamic stability of their protein disulfides, nor is there a reliable, sufficient supply of ATP to support the ongoing synthesis of the three groups of "testing" proteins (protein disulfide isomerases, peptidyl prolyl isomerases and molecular chaperones)

doi: 10.3389/fphys.2014.00516

S13A) and lipid peroxidation (Fig