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Almost all the solid evidence is from animal studies

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

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Y., Ma F., et al., Genomewide Screen Identifies Curli Amyloid Fibril as a Bacterial Component Promoting Host Neurodegeneration, PNAS 118, no

doi: 10.1096/fj.13-231381 100 ClementSRefetoffSRobayeBDumontJESchurmansS

A rare case of prurigo pigmentosa in a Danish sibling couple