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Main Study Findings and Authors Conclusions Table 8Summary of Findings Included Systematic Review and Meta-Analysis OR = Odds Ratio, CI = Confidence Interval, RRR = Relative Risk Reduction, NNT = Number Needed to Treat Table 9Summary of Findings of Included Non-Randomized Study Table 10Summary of Recommendations of Included Guidelines RCT = Randomized Controlled Trial, CI = Confidence Interval Appendix 5

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XiaLSunCZhuHZhaiMZhangLJiangLet alMelatonin protects against thoracic aortic aneurysm and dissection through SIRT1-dependent regulation of oxidative stress and vascular smooth muscle cell loss