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Figure 2 Figure 3 5 Potential therapeutic strategies for OA targeting the gut microbiota-ferroptosis axis Based on the innovative hypothesis of the gut microbiota-ferroptosis axis, dual-target compounds such as resveratrol, and salidroside show potential therapeutic value in improving the progression of OA by synergistically modulating the gut-joint axis and inhibiting the ferroptosis cascade reaction

As a result of these properties, MSNs can be considered as possible applicants of a broad spectrum of applications in pharmaceutics, biomedicine, and biotechnology