glutathione gsh biosynthesis pathway Glutathione: an overview of and modulation One-carbon metabolism and glutathione (GSH)

Further, these data suggest that at acute time points following Gclc genetic deletion, compensation by NRF1 could be responsible for the dispensable role of NRF2 in GSH-depleted conditions

Abbreviations ER endoplasmic reticulum IMM inner mitochondrial membrane GCL glutamate-cysteine ligase GPx glutathione peroxidases GR glutathione reductase Grx Glutaredoxin GS glutathione synthetase GSH reduced glutathione GSSG oxidized glutathione GSH/GSSG ratio between reduced and oxidized glutathione GST glutathione S-transferase MOM mitochondrial outer membrane mtGSH mitochondrial glutathione OGC 2-oxoglutarate carrier ROS reactive oxygen species SLC soluble carrier protein TR thioredoxin reductase Trx Thioredoxin xCT cystine/glutamate antiporter SLC7A11 Footnotes Conflicts of interest J.W

doi: 10.3389/fimmu.2025.1727122 93 GuoQJinYChenXYeXShenXLinMet al

Ischemic Postconditioning regulates new cell death mechanisms in stroke: Disulfidptosis

[90] pre-treated lymphoma cells co-cultured with CD8+ T cells derived from healthy donors with 1 mM VitC

Wyness LA, McNeill G, Prescott GJ