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Risk assessments for human inhalation toxicity based on traditional animal studies generally include a safety factor of 25 to account for uncertainties related to interspecies (animal-to-human: 2.5-safety factor) and inter-individual (human-to-human: 10-safety factor) variabilities ( in vitro PoDs from MucilAir readouts (i.e., TEER, lactate dehydrogenase leakage and resazurin metabolism analyses) with dosimetry information obtained from a computational fluid-particle dynamics (CFPD) model (Ramanarayanan et al., 2022)

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Fertil Steril 2008;90:Suppl:S260-S269 Yap C, Funress S, Farquhar C

To further understand the potential roles of allicin in stroke, allicin was administered to mice by intraperitoneal injection 2 h after PT stroke daily for 14 consecutive days, and behavioral testing was performed on days 3, 5, 7, and 14 after stroke (Fig