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Heavy smokers and drinkers can also have low levels of B12

Our in vitro experiments on human primary monocytes show that the glutathione metabolism is involved in the regulation of the acute response to BDG at the transcriptomic and molecular levels, yet further studies are required to evaluate the functional impact of this phenomenon in vivo

M., Binobead, M

Further exploration of other in vivo tumor models as well as clinical studies is necessary to determine whether the limited dependence of some tumor cells on glutamine anaplerosis is associated with select oncogenic contexts or tissues of origin, or whether it reflects glutamine availability in the specific tissue environments

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Key genes include CTNNB1 (-catenin), APC, AXIN1/2, GSK3B, LRP5/6, TCF7 and LEF1