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Third, we chose to use overall survival as the primary endpoint, which is a hard outcome, providing a comprehensive assessment of the treatment effect in a retrospective study, although the proportion of patients becoming non-self-sufficient and ALSFRS-R total score, used as secondary outcomes, are validated endpoints for trials in ALS

coli LMG194 (a 23-fold increase compared with the overproducing E

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Tharyan RG et al (2020) NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin