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Ueland, O

2008, 5 (Suppl 2): 702-707

Metabolic drift in the aging nervous system is reflected in human cerebrospinal fluid

Surpassed the root mean square (RMS) response strength of ECT and standard antidepressants at 30 mg/kg at 1 and 10 mg/kg

512 This intuitively seems contradictory, as -cell loss in T2D patients should decrease IAPP production and secretion, possibly suggesting that IAPP aggregates may form at an earlier stage of the disease, where insulin resistance causes still highly functional -cells to upregulate their secretory activities

Pickart (2008) reviewed the broader tissue remodeling context and argued that GHK operates as a damage signal released from injured or aging tissue, recruiting repair processes that decline as the signal itself becomes less abundant