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[DOI] [PubMed] [Google Scholar] 75.Smith FW, Ealing PM, Hawkesford MJ, and Clarkson DT

These results are backed up by the finding of a strong increase of the concentration of Pycnogenol s metabolites and components in the synovial fluid, surrounding articular cartilage in the joints in osteoarthritis patients ( intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage ( contributes to restoring health in damaged joints

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Acknowledgements The authors are thankful to the Director, ICMRNIOH Ahmedabad, for providing the necessary infrastructure for conducting this study