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Laboratory studies have investigated MOTS-c for roles in cellular metabolism, AMPK signalling, and metabolic stress responses

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Preclinical research suggests 5-Amino-1MQ inhibits NNMT, affecting nicotinamide metabolism and NAD+ availability in studied cell types

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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone