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Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

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[DOI] [PubMed] [Google Scholar] Alba-Bernal A, Godoy-Ortiz A, Dominguez-Recio ME

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Moreover, the study found that the Ruminococcaceae family and the Prevotella genus were significantly elevated in the poor outcome group (defined as those with an mRS score 3) compared to the good outcome group