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Once inside, it is chemically converted into cysteine, which then serves as the rate-limiting substrate for -glutamyl cysteine synthetase, the first enzyme in the synthesis pathway of the endogenous antioxidant glutathione (Arakawa & Ito, 2007)

and failing to assess essential minerals loss and ensuring that minerals were appropriately supplemented to avoid health consequences

Targeting HIF-1 abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues

doi: 10.3390/ph11010002 43

(2022) 6:e437
