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33 In a study of GSH systemic availability by Witschi et al showed that it is impossible to boost serum GSH level to a clinically beneficial level even after oral administration of a high single dose of 3 g

for example, caffeine can activate TRPA1 in mice but suppresses it in humans (Nagatomo and Kubo, 2008)

[DOI] [PubMed] [Google Scholar] 35.Yoshikawa F, Uchiyama T, Iwasaki H, Tomomori-Satoh C, Tanaka T, Furuichi T, Mikoshiba K

Prostaglandin E can enhance the transmission between glutamatergic neurons through inhibition of astrocytes and re-uptake of glutamate, which is an excitatory neurotransmitter in the central nervous system, resulting in apparent excitatory neurotoxicity in the central nervous system (121, 122)