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Titcomb, S.M

J Taiwan Inst Chem Eng

80 Senescent RPE cells secrete SASP factors like interleukins (IL-6, IL-8), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs), which promote inflammation, neovascularization, and extracellular matrix remodeling

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A reciprocal interaction supports this upstream convergence, whereby SIRT1 deacetylates LKB1, a kinase that activates AMPK, and AMPK increases NAD availability to promote SIRT1 activity (114)

[DOI] [PMC free article] [PubMed] [Google Scholar] 324.Kurnik M., Sahin C., Andersen C.B., Lorenzen N., Giehm L., Mohammad-Beigi H., Jessen C.M., Pedersen J.S., Christiansen G., Petersen S.V., et al