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the treatment also increased the expression of antioxidant genes, such as Hmox1 , Nqo1 , Cat, and Sod1 , enhanced NRF2 activity, decreased the expression of Nox4 , and attenuated the levels of intracellular reactive oxygen species

However, the interaction surface of p65 does not appear to include the DNA-binding domain, suggesting that inhibition may occur through allosteric modulation

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Zhang, X., Zhao, Q., Wen, L., Wu, C., Yao, Z., Yan, Z., et al., Front

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