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This study identified a rare nonsense mutation in the gene encoding Hdc , the rate-limiting enzyme in histamine synthesis, as being associated with TS in a two-generation pedigree (Ercan-Sencicek et al., 2010)

also indicated in their study that long-term training favors the M2 phenotype to promote recovery and metabolic remodeling, while acute exercise initiates M1 activation to respond to immune stress (42)

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For example, the expression of rice OsGPX2 and OsGPX4 was upregulated after drought and oxidative stresses but downregulated under salt and cold stresses (Islam et al., 2015a)

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