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Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)

In one study, overexpression of miR-378 in the mouse ovarian bursa led to a decrease in ovarian size and pups, illustrating this phenomenon [230]

PubMed Goldstein, A.L., Hannappel, E., Sosne, G., & Kleinman, H.K

2024;11:e2309290

These features enable loading of drug-loading capacity (both hydrophilic and hydrophobic), stability, biodistribution, and intracellular delivery of antiretroviral (ARV) agents [8]