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Complementing these findings, a casecontrol study showed significantly elevated serum creatinine, blood urea nitrogen (BUN), and urinary protein levels in PD patients, which positively correlated with HoehnYahr stage and motor symptom severity [148]

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Study Comparing the Efficacy and Safety of Vanucizumab and FOLFOX with Bevacizmab and FOLFOX in Participants with Untreated Metastatic Colorectal Cancer (McCAVE)

For bioconjugation of Fc, human IgG1 Fc has been widely used, although it has disadvantages such as antibody-dependent cell cytotoxicity (ADCC) and complementary-dependent cytotoxicity (CDC) 12

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doi:10.3389/fendo.2020.00624