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In hepatocellular carcinoma, CTNNB1-activating mutations [28% (34/123) to 40% (18/45)] are the most significant genetic changes in the Wnt/-catenin pathway

The present study provides evidence that increased OS within the aged ovary, elicits a concomitant increase in the electrophilic aldehyde by-product of 4-HNE, which appears to selectively accumulate within the oocyte

10.1007/s13197-019-04142-5

The result will be a very elevated value without clinical utility

Ichijo H et al (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways