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These immune cells release a cascade of pro-inflammatory cytokines, including interleukin-1 beta (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and interferon-gamma (IFN-)

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doi: 10.3389/fcell.2025.1598924 Received 24 March 2025 Accepted 07 July 2025 Published 18 July 2025 Volume 13 - 2025 Edited by Junqi Huang, Jinan University, China Reviewed by Anna Martina Battaglia, Magna Grcia University of Catanzaro, Italy Cadiele Oliana Reichert, University of So Paulo, Brazil Updates Copyright 2025 Fan, Xu, Gao, Zhang, Wang, Shan, Luo, Fei and Cai

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Immunological dysfunction and mast cell activation syndrome in long COVID

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