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[DOI] [PubMed] [Google Scholar] Field DT, Cracknell RO, Eastwood JR, et al

Korzystne efekty na wydluzenie mieszka i komorki brodawki obserwowano miedzy 10^-12 a 10^-9 M, podczas gdy wyzsze stezenia, od 10^-8 do 10^-7 M, dzialaly hamujaco (Pyo i in., 2007)

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Inhibitors of FAK that target the ATP-binding pocket of the kinase domain have been largely unsuccessful 10,11 , displaying micromolar anti-proliferative effects and no apoptotic effects in cancer cells despite reported nanomolar biochemical potencies for the FAK enzyme 12,13

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These findings highlight that gut microbial alterations, beyond just TMAO elevation, may contribute to cerebrovascular disease progression (Yin et al., 2015)