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For cats, obtaining B12 adequately from their diet is generally not a problem

Route Topical / transdermal Published Dose Context Marketed by some clinics and compounders, but no published human exposure data was identified in FDA's December 2024 evaluation

J Neurol 238(5):262264

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headaches, brain fog, GI irregularity, dizziness, and other complications

Nerves were dissected under sterile conditions, stripped of epineurium, cut into small pieces, and digested with 0.05% collagenase/dispase (Roche, Cat#10269638001) for 1 h at 37 C, followed by 0.25% trypsin (Gibco, Cat#25200056) for 15 min