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Research on brainstem mechanisms of amylin-induced anorexia confirmed that amylin-responsive and GLP-1-responsive neurons are largely separate populations

Since glutathione and pyruvate are antioxidants, glycolytic inhibition limited cells reductive capacity and increased their susceptibility to oxidative stress

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The disruption in various systems further results in the imbalance of glucose and lipid metabolism, with multiple organs involved, promoting the onset and progression of MASLD

System Xc is an antiporter composed of SLC7A11 and SLC3A2, which mediates the cellular uptake of extracellular cystine for GSH synthesis ( 3 Ferroptosis in PCOS 3.1 Core pathophysiological features of PCOS and ferroptosis Ovulatory dysfunction in PCOS often leads to oligomenorrhea or amenorrhea, which reduces iron loss through menstruation