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Cancer cells express a variety of inflammatory mediators, such as cytokines and chemokines

Acknowledgment This work was supported by a Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC no

However, recent research has uncovered a broader range of pathophysiologic mechanisms contributing to disease progression [144,145,146,147]

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For example, under the stimulation of pro-inflammatory cytokines, transcription factors NF-B and STAT3 can promote the expression of oncogenes to promote tumorigenesis and metastasis

[14] demonstrated that application of H 2 O 2 at low concentrations induces stress tolerance in plants due to the induction of the synthesis of certain substances similar to other normally synthesized during chilling stress