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Stability: GHK-Cu is enzymatically degraded by serum proteases relatively quickly, which is why topical formulations often include penetration enhancers (like DMSO or liposomes) to improve dermal delivery before breakdown occurs

4.3 Limitations and strengths First, to ensure data quality and completeness, the data in this study were obtained exclusively from the WoSCC database

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The types of studies available (RCTs, observational studies), quality of individual studies, consistency of outcome across studies, and generalizability of samples, settings, and interventions were examined, and overall evidence strength determined

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