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This process is facilitated by the protonation of amine groups grafted onto the polymer surface within endosomes (pH 56) and lysosomes (pH 45), which possess strong proton-buffering capacity and induce rapid osmotic swelling, thereby promoting cargo release
Receptor adaptation

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Incident users analysis revealed inconsistent findings which could be potentially explained with time-dependant non-linear association between effect of statins on cognitive processes or through differences and selection of these users
Brooks BR, et al