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MTAP deficiency-induced metabolic reprogramming creates a vulnerability to Cotargeting De novo purine synthesis and glycolysis in pancreatic Cancer

"Societe de Chimie Biologique, Louis Pasteur Medal

Therefore, more effective therapies are desperately needed

It should be stressed that the lowest concentration of iodine used in this study, i.e., 2.5 mM, corresponds to the same order of magnitude of iodine concentrations causing WolffChaikoff effect, i.e., 10 3 M (1 mM) [95]

IDH mutations are common in malignant cancers and are particularly more prevalent in secondary gliomas than in primary gliomas [188]

Y.WangY.MaS.ChenX.ChenJ.et al (2016)