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In the case of cells lacking the activity of transcription factor Msn4p, a smaller increase about 3.5-fold in the activity of the enzyme was noted in samples incubated in conditions of mild heat stress or mild osmotic stress and in the presence of DMSO at concentrations of 610%

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Individuals with severe kidney or liver disease, certain genetic disorders, or those who are pregnant or breastfeeding should avoid glutathione unless cleared by a physician

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