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continue vitamin supplementation during treatment and for 21 days after the last dose of pemetrexed to reduce the severity of hematologic and gastrointestinal toxicity of pemetrexed [see Dosage and Administration (2.4)]

Curr Protoc Mouse Biol, 2020, 10(1): e68

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With careful oversight and personalized dosing, it can significantly improve health outcomes related to hematological and neurological wellbeing