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2.2.1.1 Decision triggers for disassemblyreassembly selection The primary utility of this strategy lies in early-stage exploratory research where maximum cargo versatility and proof-of-principle functional delivery are prioritized over immediate scalability or rigorous product homogeneity

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Although we may not have sufficient power to detect significant changes in our secondary outcomes (tau PET, MRIs, CSF AD biomarkers and cognition), including a nine-month follow-up will help provide preliminary evidence of successful modification of disease trajectory over a one-year period

95% CI, 0.931.26) in patients treated with roxadustat versus those treated with placebo ( versus ESA in patients with NDD-CKD or incident-to-dialysis CKD (n = 2,142), no evidence of increased risk was observed for MACE (HR 0.79