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Diano, et al

Toxicol in Vitro

Thus, DPP4 has been proposed to indirectly regulate bone remodeling by interacting with other adipokines such as leptin and adiponectin and by degrading its substrates including neuropeptides, incretins, and gastrointestinal peptides within the bone marrow niche (549)

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However, we are answering the question about opioid impacts the best way we can without exposing patients to the risks and side effects of this class of medications. The types of opioids, as well as the dose patients were taking, varied significantly
Asztalos, B