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While eumelanin is responsible for brown skin tones, pheomelanin is responsible for red or yellow skin tones

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Synthetic inhibitors of aldose reductase have severe side effects including elevations in blood liver enzymes from hepatotoxicity, as well as nausea and vomiting

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Quillinan N., Lau E.K., Virk M., von Zastrow M., Williams J.T

doi:10.1161/cir.0000000000000748 Heber S, Fischer B, Sallaberger-Lehner M, et al

Future clinical practice may pay more attention to personalized treatment, adjusting treatment plans by assessing patients vitamin D levels to achieve the best therapeutic effects and minimal side effects, which is conducive to improving patients treatment experience and clinical prognosis