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Infiltrating M1 macrophages exhibit a pro-inflammatory phenotype in the CNS, releasing high levels of TNF- (76), while neutrophils release TNF- through NETs (77)
Data were recorded for all patients older than 18 years of age who were prescribed VB12 during January 2014December 2017
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Specifically, they show an early increase in DA neuron counts in the SNcVTA region and elevated striatal DA levels preceding chorea and non-motor symptoms 46
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