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For chemotherapy side effects, a review of potential side effects and reassessment and making improvements after each cycle should be the goal

[PMID: 7672658] [DOI] [PMC free article] [PubMed] [Google Scholar] Corrao 1998a Corrao G, Zambon A, Torchio P, Arico S, Vecchia C, Orio F

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Sustained drug treatments suppress tumor angiogenic activity, leading to tumor-associated hypoxia, which promotes the selection of resistant cell clones adapted to oxygen and nutrient deprivation, thereby limiting drug efficacy [48]