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Increased 8-hydroxydeoxyguanosine in high-grade gliomas is associated with activation of autophagy

This observation is consistent with the DRB1*15:01 allele belonging to one of the three oldest ancestral haplotypes (DR2-DQ6, DR3-DQ2, and DR4-DQ8), which have survived over time due to their ability to recognize a greater diversity of antigens, allowing them to detect and eliminate a greater number of pathogens (113, 114)

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Clinical outcomes following termination of immunotherapy due to long-term benefit in MSI-H colorectal cancer

Both the excitatory and inhibitory components (such as NMDARs and GABA A Rs) are crucial in the maintenance of this delicate process, and dysregulation of either likely serves as a pathophysiological process in schizophrenia

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