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304 Studies have shown that hordenine decreases the expression of proinflammatory cytokines by suppressing the S1P/S1PR1/STAT3 pathway and promotes the healing of colonic ulcers by regulating the expression of tight junction proteins, including occludin and ZO-1

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doi: 10.1007/s00213-012-2945-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 50.Smail-Crevier RL, Maracle AC, Wash SIJ, Olmstead MC