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Highcertainty evidence from up to 14 studies in around 3700 participants consistently shows a small clinical benefit for memantine versus placebo: clinical global rating (CGR): 0 Aarsland D, Ballard C, Walker Z, Bostrom F, Alves G, Kossakowski K, et al

EDIT: Your post intrigued me and I was a bit concerned about the assumption that normal ferritin levels meant that haemochromotosis is not present
Researchers are investigating whether NNMT inhibition modulates the cellular metabolic responses to repeated contractile stress, potentially explaining the differential metabolic profiles observed when combining NNMT inhibition with exercise protocols in research models

Holubeck et al., 2024) or peptide hormones and their releasing factors, growth factor modulators, and metabolic modulators

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