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Through genomic actions via nuclear thyroid hormone receptorsThyroid Hormone Receptor Alpha (TR) and Thyroid Hormone Receptor Beta (TR) and rapid non-genomic effects, thyroid hormones influence neuronal differentiation, synaptic plasticity, neurotransmitter turnover, and mitochondrial bioenergetics (1721)

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But the triggering conditions under which phase II metabolites are converted back into UA monomers have not yet been reported, indicating a need for more research in this area

Entacapone is a reversible inhibitor of COMT, while tolcapone is a reversible inhibitor of both COMT and another enzyme called COMT-B

10.1080/10715762.2019.1661404 98 ZengJ.LiuJ.NiH.ZhangL.WangJ.LiY.et al (2023)